Organic Lecture: Dr. Liu, Wenbo

Tital: Development of N-Aryl Phosphoramidites and Aplication in Iridium-Catalyzed Asymmetric Allylic Substitution Reactions&Direct C–H Silylation of Heteroaromatics by an Earth-Abundant Metal Catalyst

Speaker: Dr. Wenbo Liu，postdoctoral fellow, California Institute of Technology, USA. 

Date: Jan.  6, 2015  10:10AM

Place: Room 1002 of Chemistry building , Chang’an Campus

Abstract

1)Allylic alkylation chemistry represents asuccessful strategy for the assembly of highly congested chemical architectures and,within this domain,Ir-catalyzed asymmetric allylic substitutions are among the most selective and highest yielding for the synthesis of branched allyl compounds.A series of N-aryl phosphoramidite ligands were synthesized and applied in Ir-catalyzed chemistry,with excellent regioselectivity and enantioselectivity.

2)Organosilanes are important synthetic intermediates and core molecular architectures in organic electronic materials and polymers,medicinal chemistry and drug discovery,and various biomedical applications.We have developed anovel,general and cost-effective catalytic method for C–Si bond construction,using transition-metal-free catalyst,proceeding under mild and solvent-free conditions with minimal waste,and with awide range of substrate classes.

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Wang, Yaoyu

Prof. Wang’s group has five teachers and fifteen graduate students. The research interests of the group mainly focus on the functional coordination chemistry and materials chemistry. The group has started to explore a totally new field about molecular braid, synthesized the first case of novel [4]-crossing catenane coordination polymer, and found the catalyst of decarboxylation in the in situ reaction.

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